LDL and HDL
Cholesterol
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LDL and HDL
Cholesterol
Lipoproteins are the carriers of lipids in the blood. They are
named chylomicrons, very low density lipoproteins (VLDL), low
density lipoproteins (LDL) and high density lipoproteins (HDL)
on the basis of their components, size & density.
Low density lipoproteins are also known as "bad
cholesterol." High density lipoproteins are sometimes called
"good cholesterol." The reasons will become obvious below.
How LDL & HDL are formed
Lipids in the diet are digested & absorbed into the
blood in the form of free fatty acids and chylomicrons.
Chylomicrons are composed of protein, phospholipid, cholesterol
& triglycerides. Liver breaks down the remains of
chylomicron & other lipids, to produce VLDL (very low
density lipoprotein). The VLDL, while circulating loses some of
their triglycerides to the fat depots & is ultimately
converted into LDL (low density lipoprotein). The LDL’s are
again taken up by the lever & degraded. The LDL is also
taken up by a kind of defense cells called Macrophages, which
are then converted into foam cells and become instrumental for
development of clogging of arteries. After degradation of LDL
inside the cells, the lipids are packed in HDL.
Ways to Beat High
Cholesterol
How dangerous is cholesterol?
Fats including cholesterol cannot dissolve in the blood or
water. So they bind to the lipoproteins to travel in the
body.
LDL cholesterol is considered as ‘bad’ cholesterol. Because,
elevated levels of LDL cholesterol combined with other fats
tends to get attached in the inner walls of the arteries which
will reduce the inner dimensions of the arteries causing raise
in blood pressure in the initial stages. It may clog the whole
artery sometimes, making the blood flow almost impossible.
Sometimes, these deposits may get detached from the wall &
run in the blood. They get blocked in smaller vessels,
completely cutting off the supply to that particular organ. For
example, if this plaque blocks the blood flow to the heart, it
causes heart attack and failure, when it get blocked in an
artery that supplies the brain, ends up in a stroke.
On the other hand, HDL cholesterol is the good variety of
fat, as it does not allow adhesion of harmful cholesterol in
arteries & reduces the incidences of heart attack &
strokes. Having too less of concentration of HDL also increases
the risk of heart failure.
Triglycerides: Elevated triglycerides often have a high
total cholesterol lever especially high LDL & low HDL
concentrations.
Lp (a) cholesterol: It is similar form of LDL cholesterol
with significant risks for the development of clogs in the
arteries.
Hence, the ratio of LDL & HDL concentration is important
to assess the risk of heart & vascular diseases.
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